The liver is one of the most important organs in the body. It is essential to have a healthy liver as it performs essential and critical functions like filtering blood and getting rid of toxins from your body. A liver transplant is a last-resort therapeutic solution for both severe acute (sudden onset) and chronic (long-term) liver diseases.

Nanavati Max Hospital’s Liver Transplant Facility, a part of the Centre for Hepato-Pancreatic-Biliary Surgery & Liver Transplant, is a specialised unit offering complete treatment to patients with severe or end-stage liver disease. It is one of the finest hospitals for liver transplants in Mumbai for end-stage liver disease (ESLD). Its liver transplant unit in Mumbai provides cutting-edge treatment with thorough pre- and post-liver transplant monitoring.

10 Reasons you Might Need a Liver Transplant

The doctor might advise a liver transplant if a patient has end-stage liver disease. Without a transplant, a person with this illness will eventually succumb to it. Additionally, your doctor could recommend a liver transplant if various liver disease therapies are ineffective.

Liver transplantation is indicated if you have chronic liver disease or if your liver starts to fail rapidly. The most frequent cause of adult liver transplantation is cirrhosis. Healthy liver tissue is replaced by scarred tissue due to cirrhosis. The following contribute to cirrhosis of the liver:

1. Alcoholism

The most frequent reason for liver transplantation is liver failure brought on by excessive alcohol consumption.

2. Chronic hepatitis B or C

Globally, it is the most common reason for orthotopic liver transplantation (OLT). It is a liver disease caused by chronic viral hepatitis.

3. Non-alcoholic steatohepatitis (NASH)

NASH is a non-alcoholic fatty liver disease resulting from the deposition of fat inside the liver cells. This inflammation damages and scars the liver. Fatty liver and NASH are more likely to happen if you are overweight or have metabolic diseases like diabetes or high cholesterol (increased cholesterol).

4. Autoimmune hepatitis

A liver transplant may be necessary in cases of untimely diagnosis and treatment of autoimmune hepatitis, insufficient response or intolerance to immunosuppressive treatments, or where patients do not adhere to the prescribed course of action.

5. Biliary Atresia

Biliary Atresia affects infants and is a degenerative, fibro-obliterative condition of the internal and external-hepatic bile ducts. Most infected children will ultimately develop end-stage liver disease and need a liver transplant.

6. Metabolic Problems

Liver transplantation may effectively treat several inborn metabolic defects. Despite medication and nutritional therapy, patients with severe illness symptoms or life-threatening metabolic decompensations may considerably improve their quality of life with a liver transplant.

Your doctor will also consider other aspects when deciding if you need a liver transplant. These consist of the following:

7. Liver Cancer

Surgical resection (removal of the tumour by surgery) or liver transplantation are the best treatments for liver cancer. Other forms of therapy, such as ablation or radiation, may also be effective in curing small liver tumours. However, a liver transplant is not an option if cancer has progressed outside the liver or developed into a blood artery.

8. Depends on the Severity of your Illness

Liver transplantation is typically reserved as a medical option for individuals with end-stage chronic liver disease. However, in rare instances of abrupt failure of a previously healthy liver, liver transplantation may be the only option for treatment.

9. Medical History of TB or Long-Term Infections like HIV

Liver illness may be brought on by hepatic tuberculosis or may be aggravated by antitubercular medication therapy. Furthermore, HIV infection increases the chance of liver issues. The liver may become inflamed due to several anti-HIV medications, notably nevirapine (Viramune). Vitamin A in very high concentrations may potentially harm the liver.

10.  General Medical Health

Some liver issues are inherited and lead to a hereditary illness (the ones you inherit from your parents). Hemochromatosis, Wilson disease, Tyrosinemia, and other inherited liver disorders are a few examples.

Additionally, if you suffer from one of these autoimmune illnesses, your doctor might advise a transplant:

• Caroli’s illness, which causes abnormalities in the bile ducts inside the liver;
• Primary Sclerosing Cholangitis (PSC), which causes cholestasis brought on by TPN; and
• Neonatal Sclerosing Cholangitis includes the loss of bile ducts both from within and outside the liver.

Total parenteral nutrition (TPN) patients may have bile stasis (slowing or halting of normal bile flow), which can eventually result in liver damage and failure.

Conclusion

Thus, we see that several underlying causes may necessitate a liver transplant. Several hospitals in Mumbai, including Nanavati Max Hospital, provide world-class liver transplant treatment, making the city a preferred option for those requiring this life-saving procedure.

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